Jm32 king v4/3/2024 Furthermore, fibroblast to myofibroblast differentiation drives effective wound healing and is largely regulated by the cytokine, transforming growth factor-β1 (TGF-β1). Compared with adult cells, differences were observed in nestin and smooth muscle actin (SMA) expression at the protein and transcript level. Although subtle variances in expression profiles of children and neonates were observed, the two groups differed significantly from adult cells. ![]() ![]() Based on our previous results on crosstalk between neonatal fibroblasts and adult keratinocytes, the present study focused on characterization of fibroblasts prepared from cleft lip tissue samples of neonates and older children, and compared them with samples isolated from normal adult skin (face and breast) and scars. ![]() Clinical data demonstrated improved and almost scarless neonatal healing of reparative surgery. The nonsyndromic cleft is one of the most frequent congenital defects in humans.
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